James Gangala was born at Montebrandone, Ancona. He studied law and then joined the Franciscans at Assisi in 1416. He studied under St. Bernardino of Siena at Fiesole, was ordained when he was twenty-nine, and became an effective and forceful preacher. He worked as a missionary with St. John Capistran in Italy and in Germany, Bohemia, Poland, and Hungary, and in 1426, with John, was named inquisitor against the Fraticelli by Pope St. Martin V.
He was canonized in 1726 as St. James of the Marches. His feast day is November 28th.